產(chǎn)品屬性：
產(chǎn)品名稱 | U-0126 |
規(guī)格 | 1mg、5mg、10mg、25mg |
貨號(hào) | EY-01Y9698 |
Cas No.: 109511-58-2
別名: N/A
化學(xué)名: 2,3-bis[amino[(2-aminophenyl)thio]methylene]-butanedinitrile
分子式: C18H16N6S2
分子量: 380.5
溶解度: 0.5mg/mL in ethanol, 25mg/mL in DMSO, 30mg/mL in DMF
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively. [1] It is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK and it shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3, MKK-4, MKK-6, Cdk2, and Cdk4. However, U-0126 does phosphorylate and activate AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 15 μM in HEK293 cells).[2] It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
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