產品屬性：
產品名稱 | RA375 |
規格 | 5 mg、10 mg、50 mg、100 mg |
貨號 | EY-01Y10333 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C30H25ClN4O7
分子量: 589
溶解度: DMSO : 125 mg/mL (212.22 mM; Need ultrasonic)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead[1].RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1].[1]. Ravi K Anchoori, et al. Structure-function Analyses of Candidate Small Molecule RPN13 Inhibitors With Antitumor Properties. PLoS One. 2020 Jan 15;15(1):e0227727.
特別提醒公司產品僅供科研使用
