產(chǎn)品屬性：
產(chǎn)品名稱 | STING Agonist 1a |
規(guī)格 | 500 μg、1 mg、5 mg、10 mg |
貨號 | EY-01Y10534 |
Cas No.: 652142-94-4
別名: N/A
化學(xué)名: N/A
分子式: C19H11Cl2N5O
分子量: 396.2
溶解度: DMF: slightly soluble,DMSO: slightly soluble,PBS (pH 7.2): slightly soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
STING agonist 1a is an agonist of stimulator of interferon genes (STING).1 It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50 = 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . 1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screeningBioorg. Chem.100103958(2020)
特別提醒公司產(chǎn)品僅供科研使用
