產品屬性：
產品名稱 | R-8507 |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y10764 |
Cas No.: 338773-13-0
別名: N/A
化學名: N/A
分子式: C16H8ClF3N4
分子量: 348.7
溶解度: DMF: 16 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 2 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.
特別提醒公司產品僅供科研使用
