產(chǎn)品屬性：
產(chǎn)品名稱 | TIE-2/VEGFR-2 kinase-IN-1 |
規(guī)格 | 10mM*1 mL in DMSO、1mg、5mg |
貨號 | EY-01Y12779 |
Cas No.: 453590-24-4
別名: N/A
化學(xué)名: N/A
分子式: C13H11N3O2
分子量: 241.25
溶解度: DMSO: 5 mg/mL (20.73 mM; ultrasonic and warming and heat to 80°C)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis[1].Angiopoieten 1 is a ligand for the endotheiium-specific receptor tyrosine kinase, TIE-2 is a novel angiogenic factor[1].Inhibition of TIE-2 is expected to serve to disrupt remodeling and maturation of new vasculature initiated by angiogenesis thereby disrupting the angiogenic process. Inhibition at the kinase domain binding site of VEGFR-2 would block phosphorylation of tyrosine residues and serve to disrupt initiation of angiogenesis.[1]. Jerry Leroy Adams, et al. Furo-and thienopyrimidine derivatives as angiogenesis inhibitors. Patent WO2003022852.
特別提醒公司產(chǎn)品僅供科研使用
