產(chǎn)品屬性：
產(chǎn)品名稱 | Prosaptide TX14(A) (trifluoroacetate salt) |
規(guī)格 | 500 μg、1 mg、5 mg、10 mg |
貨號 | EY-01Y13365 |
Cas No.: N/A
別名: N/A
化學(xué)名: N/A
分子式: C69H110N16O26·XCF3COOH
分子量: 1579.7
溶解度: DMF: 1 mg/ml,DMSO: 1 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Prosaptide TX14(A) is a peptide fragment of the neurotrophic factor prosaposin and an agonist of GPR37L1 and GPR37.1 It activates ERK signaling in HEK293T cells expressing GPR37L1 or GPR37 (EC50s = 5 and 7 nM, respectively) and inhibits forskolin-induced cAMP production in the same cells. Prosaptide TX14(A) (100 nM) protects primary mouse astrocytes from hydrogen peroxide-induced cell death. It reduces allodynia in a variety of rat peripheral pain models, including models of diabetic neuropathy and sciatic nerve hemiligation when administered at a dose of 4 mg/kg, as well as prevents paw allodynia induced by formalin at 1 mg/kg.21.Meyer, R.C., Giddens, M.M., Schaefer, S.A., et al.GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposinProc. Natl. Acad. Sci. USA110(23)9529-9534(2013)
2.Jolivalt, C.G., Ramos, K.M., Herbetsson, K., et al.Therapeutic efficacy of prosaposin-derived peptide on different models of allodyniaPain121(1-2)14-21(2006)
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