產(chǎn)品屬性：
產(chǎn)品名稱 | SH-42 |
規(guī)格 | 1 mg、5 mg、10 mg、25 mg |
貨號 | EY-01Y14742 |
Cas No.: 2143952-36-5
別名: N/A
化學(xué)名: N/A
分子式: C25H38O4
分子量: 402.6
溶解度: Chloroform: 10 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
SH-42 is an inhibitor of ?24-dehydrocholesterol reductase (DHCR24; IC50 = 4.2 nM).1 It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E2 , as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A .21.Müller, C., Hemmers, S., Bartl, N., et al.New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductaseEur. J. Med. Chem.140305-320(2017)
2.K?rner, A., Zhou, E., Müller, C., et al.Inhibition of δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolutionProc. Natl. Acad. Sci. USA116(41)20623-20634(2019)
特別提醒公司產(chǎn)品僅供科研使用
