產(chǎn)品屬性：
產(chǎn)品名稱 | QM385 |
規(guī)格 | 1mg、5mg |
貨號(hào) | EY-01Y15212 |
Cas No.: 2296727-52-9
別名: N/A
化學(xué)名: N/A
分子式: C18H19F3N6O2
分子量: 408.38
溶解度: DMSO: 125 mg/mL (305.35 mM)
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1].IC50: 1.49 nM (Sepiapterin reductase)[1]QM385 effectively inhibits the proliferation of human CD4+ T cells at low doses[1].[1]. Cronin SJF, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 Nov;563(7732):564-568.
特別提醒公司產(chǎn)品僅供科研使用
