產品屬性：

Cas No.: 1310012-15-7

別名: N/A

化學名: N/A

分子式: C21H22D3N.HCl

分子量: 330.9

溶解度: DMF: 14 mg/ml,DMSO: 10 mg/ml,Ethanol: 30 mg/ml

儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Terbinafine-d3 is intended for use as an internal standard for the quantification of terbinafine by GC- or LC-MS. Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. mentagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml).1 It selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively).2 Terbinafine (90-120 μM) induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and human umbilical vein endothelial cells (HUVECs).3,4 Formulations containing terbinafine have been used in the treatment of nail and skin fungal infections. 1.Petranyi, G., Meingassner, J.G., and Mieth, H.Antifungal activity of the allylamine derivative terbinafine in vitroAntimicrob. Agents Chemother.31(9)1365-1368(1987)

2.Ryder, N.S., and Dupont, M.C.Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymesBiochem. J.230(3)765-770(1985)

3.Lee, W.S., Chen, R.J., Wang, Y.J., et al.In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrestInternational Journal of Cancer106125-137(2003)

4.Ho, P.Y., Liang, Y.C., Ho, Y.S., et al.Inhibition of human vascular endothelial cells proliferation by terbinafineInternational Journal of Cancer11151-59(2004)
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