產(chǎn)品屬性：
產(chǎn)品名稱 | Tauro-α-muricholic Acid-d4 (sodium salt) |
規(guī)格 | 500 μg、1 mg |
貨號(hào) | EY-01Y16805 |
Cas No.: N/A
別名: N/A
化學(xué)名: N/A
分子式: C26H40D4NO7S·Na
分子量: 541.7
溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 1 mg/ml
儲(chǔ)存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Tauro-α-muricholic acid-d4 (TαMCA-d4) is intended for use as an internal standard for the quantification of TαMCA by GC- or LC-MS. TαMCA is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid .1 TαMCA is common in rodents but has also been found in small amounts in human serum.21.Sayin, S.I., Wahlstr?m, A., Felin, J., et al.Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonistCell Metab.17(2)225-235(2013)
2.García-Ca?averas, J.C., Donato, M.T., Castell, J.V., et al.Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated methodJ. Lipid Res.53(10)2231-2241(2012)
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