產品屬性：
產品名稱 | TH5487 |
規(guī)格 | 5mg、10mg、50mg、100mg |
貨號 | EY-01Y17328 |
Cas No.: 2304947-71-3
別名: N/A
化學名: N/A
分子式: C19H18BrIN4O2
分子量: 541.18
溶解度: DMSO: 25 mg/mL (46.20 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes[1].TH5487 (5 μM; 1 hour) decreases TNFα- and LPS-induced proinflammatory gene expression to near pretreatment levels[1].TH5487 (0-10 μM; 1 hour) perturbs binding of NF-κB to 8-oxoG-containing synthetic DNA in nuclear extracts from MLE 12 or hSAEC cells[1]. RT-PCR[1]Cell Line:Murine airway epithelial cell line (MLE 12); Diploid human small-airway epithelial cell (hSAECs)TH5487 (prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours) decreases TNFα or LPS induced the robust recruitment of neutrophils to the airways, and reduces the pulmonary neutrophil count in a time-dependent manner[1].
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