產品屬性：
產品名稱 | Seltorexant |
規格 | 1mg、5mg |
貨號 | EY-01Y17619 |
Cas No.: 1293281-49-8
別名: N/A
化學名: N/A
分子式: C21H22FN7O
分子量: 407.44
溶解度: DMSO: 250 mg/mL (613.59 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1].pKi: 8.0 (human OX2R), 8.1 (rat OX2R)[1][1]. Bonaventure P, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82.
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