產品屬性：

Cas No.: 486-89-5

別名: N/A

化學名: N/A

分子式: C15H20N2O

分子量: 244.3

溶解度: DMSO: soluble,Methanol: soluble

儲存條件: Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition:Evaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Anagyrine is an alkaloid that has been found in L. albus and has nematocidal and anticancer activities.1,2,3 It binds to muscarinic and nicotinic acetylcholine receptors (AChRs) with IC50 values of 132 and 2,096 μM, respectively, in radioligand binding assays using pig brain membranes that endogenously express high levels of the receptors.1 Anagyrine decreases survival of B. xylophilus worms.2 It inhibits proliferation of TE-671 and SH-SY5Y cancer cells (EC50s = 18.1 and 19.1 μM, respectively).3 Maternal ingestion of anagyrine during gestation is associated with the teratogenic condition crooked calf disease in cattle.4 1.Schmeller, T., Sauerwein, M., Sporer, F., et al.Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptorsJ. Nat. Prod.57(9)1316-1319(1994)

2.Matsuda, K., Kimura, K., Komai, K., et al.Nematicidal activities of (-)-N-methylcytisine and (-)-anagyrine from Sophora flavescens against pine wood nematodesAgr. BioI. Chem.53(8)2287-2288(1989)

3.Green, B.T., Lee, S.T., Panter, K.E., et al.Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptorsNeurotoxicol. Teratol.32(3)383-390(2010)

4.Keeler, R.F., Cronin, E.H., and Shupe, J.L.Lupin alkaloids from teratogenic and nonteratogenic lupins. IV. Concentration of total alkaloids, individual major alkaloids, and the teratogen anagyrine as a function of plant part and stage of growth and their relationship to crooked calf diseaseJ. Toxicol. Environ. Health1(6)899-908(1976)
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