產品屬性：

Cas No.: 21104-28-9

別名: N/A

化學名: N/A

分子式: C23H25NO

分子量: 331.5

溶解度: DMSO: 10 mM

儲存條件: Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition:Evaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Mahanimbine is a carbazole alkaloid that has been found in M. koenigii and has diverse biological activities.1,2,3 It is active against S. aureus and S. pyogenes (MIC100 = 50 μg/ml for both), as well as A. aegypti fourth instar larvae when used at a concentration of 100 μg/ml.1 Mahanimbine induces cell cycle arrest at the G0/G1 phase and apoptosis in Capan-2 and SW1190 cancer cells when used at a concentration of 7 μM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 μM, respectively).2 It decreases body weight gain without affecting food intake and reduces increases in plasma total cholesterol and triglyceride levels in a rat model of high-fat diet-induced obesity when administered orally at a dose of 30 mg/kg.3 1.Ramsewak, R.S., Nair, M.G., Strasburg, G.M., et al.Biologically active carbazole alkaloids from Murraya koenigiiJ. Agric. Food Chem.47(2)444-447(1999)

2.Pei, C., He, Q., Liang, S., et al.Mahanimbine exerts anticancer effects on human pancreatic cancer cells by triggering cell cycle arrest, apoptosis, and modulation of AKT/mammalian target of rapamycin (mTOR) and signal transducer and activator of transcription 3 (STAT3) signalling pathwaysMed. Sci. Monit.246975-6983(2018)

3.Birari, R., Javia, V., and Bhutani, K.K.Antiobesity and lipid lowering effects of Murraya koenigii (L.) spreng leaves extracts and mahanimbine on high fat diet induced obese ratsFitoterapia81(8)1129-1133(2010)
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